Staufen 1 amplifies proapoptotic activation of the unfolded protein response.

Staufen-1 (STAU1) is a protein RNA-binding becomes very overabundant in various models of neurodegenerative diseases, including those who carry mutations in presenilin1 (PSEN1), microtubule-associated protein tau (MAPT), huntingtin (HTT), TAR DNA-binding protein -43 gene (TARDBP), or C9orf72.

We previously reported that the increase in STAU1 determine defects and knockdown autophagy is protective in models of several neurodegenerative diseases. Additional functional consequences STAU1 overwhelming, however, has not been investigated. We studied the role of chronic activation STAU1 in the folded protein response (UPR), a common feature of neurodegenerative diseases and are often directly related to the death of neurons.

Here we report that STAU1 is a novel modulator of the UPR, and is required for apoptosis induced by activation of a perk-CHOP. STAU1 levels increase in response to some of the endoplasmic reticulum (ER) stress, and expression of exogenous STAU1 enough to cause apoptosis through pathways of UPR perk-CHOP. cortical neurons and skin fibroblasts derived from Stau1 – / – mice showed a decrease in the UPR and apoptosis when challenged with thapsigargin.

In fibroblasts from individuals with SCA2 or with ALS causes and C9ORF72 TDP-43 mutations, we found extremely elevated levels of STAU1 and CHOP in basal conditions, and STAU1 knockdown CHOP levels returned to normal. Taken together, these results suggest that STAU1 overabundance reduce cellular resistance to ER stress and apoptosis deposition.

Spilanthol A mixture of (2E, 6Z, 8E) >80%; (2E, 6E, 8E); and (2E, 6Z, 8Z)
S681850 10mg
EUR 249
Description: 25394-57-4

Recombinant Spilanthes urens NAD (P) H-quinone oxidoreductase subunit I, chloroplastic (ndhI)
MBS1324820-005mgBaculovirus 0.05mg(Baculovirus)
EUR 1010

Recombinant Spilanthes urens NAD (P) H-quinone oxidoreductase subunit I, chloroplastic (ndhI)
MBS1324820-005mgEColi 0.05mg(E-Coli)
EUR 680

Recombinant Spilanthes urens NAD (P) H-quinone oxidoreductase subunit I, chloroplastic (ndhI)
MBS1324820-005mgYeast 0.05mg(Yeast)
EUR 840

Recombinant Spilanthes urens NAD (P) H-quinone oxidoreductase subunit I, chloroplastic (ndhI)
MBS1324820-02mgEColi 0.2mg(E-Coli)
EUR 875

Recombinant Spilanthes urens NAD (P) H-quinone oxidoreductase subunit I, chloroplastic (ndhI)
MBS1324820-05mgEColi 0.5mg(E-Coli)
EUR 965

Guest Spill Kit - EACH
X1010 EACH
EUR 89.1

Chemical Spill Kit - EACH
SAF7010 EACH
EUR 229.13

Spill Tray Liner Small - PK10
SAF7080 PK10
EUR 66.15

Spill Tray Liner Large - PK10
SAF7082 PK10
EUR 121.5

Spill Tray ABS Yellow Large
SAF7086 EACH
EUR 91.2

Spill Tray PVC White Small - EACH
SAF7070 EACH
EUR 59.4

Spill Tray PVC White Large - EACH
SAF7074 EACH
EUR 110.7

Spill Tray ABS Yellow Small - EACH
SAF7084 EACH
EUR 71.55

Spill tray, polypropylene 14" x 10" x 1"
108DST10 each
EUR 88

Spill tray, polypropylene 14" x 20" x 1"
108DST20 each
EUR 106

Spill tray, polypropylene 24" x 24" x 1"
108DST24 each
EUR 133

SILICONE SPILLPROOF TOP - 2L FOR AL HSD STMTL
100DSI02 each
EUR 166

SILICONE SPILLPROOF TOP - 5L FOR AL HSD STMTL
100DSI05 each
EUR 206

SILICONE SPILLPROOF TOP - 12L FOR AL HSD STMTL
100DSI12 each
EUR 250

SILICONE SPILLPROOF TOP - 22L FOR AL HSD STMTL
100DSI22 each
EUR 339

Sensor, acrylic block for Spill Alarm & Cut Off
108ASP-AB each
EUR 188

HiCombat Microbiology Spillage Kit
LA734-1KT 1 unit
EUR 65.38
Description: HiCombat Microbiology Spillage Kit

Aluminum Glove Box 34" x 20" w/ spill tray & hygrometer
108CGB24-20 each
EUR 1797

Aluminum Glove Box 27" x 20" w/ spill tray & hygrometer
108CGB27-20 each
EUR 2146

Aluminum Glove Box 34" x 20" w/ spill tray & hygrometer
108CGB34-20 each
EUR 2211

IKA A11.7 funnel to prevent spilling of liquid Nitrogen - EACH
MIL2146 EACH
EUR 402.3

Spill Alarm & Cut-Off - with sensor block on 6' cable. One outlet, 1500W, 120V
108ASP-1 each
EUR 814

Absorbent Chemical Spill Response Kit 15L Clip-Top Bag - EACH
SAF3722 EACH
EUR 60.81

Absorbent Chemical Spill Response Kit 20L Clip-Top Bag - EACH
SAF3724 EACH
EUR 64.04

Recombinant Morelia spilota Neurotrophin-3 (NTF3)
MBS1486858-002mgBaculovirus 0.02mg(Baculovirus)
EUR 970

Recombinant Morelia spilota Neurotrophin-3 (NTF3)
MBS1486858-002mgEColi 0.02mg(E-Coli)
EUR 530

Recombinant Morelia spilota Neurotrophin-3 (NTF3)
MBS1486858-002mgYeast 0.02mg(Yeast)
EUR 725

Recombinant Morelia spilota Neurotrophin-3 (NTF3)
MBS1486858-01mgEColi 0.1mg(E-Coli)
EUR 630

Recombinant Morelia spilota Neurotrophin-3 (NTF3)
MBS1486858-01mgYeast 0.1mg(Yeast)
EUR 845

Absorbent Chemical Spill Response Kit 80L Circular Static Bin - EACH
SAF3716 EACH
EUR 177.72

Recombinant Spermophilus spilosoma Cytochrome b (MT-CYB), partial
MBS7101092-INQUIRE INQUIRE Ask for price

Recombinant Morelia spilota Brain-derived neurotrophic factor (BDNF)
MBS1370687-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1020

Recombinant Morelia spilota Brain-derived neurotrophic factor (BDNF)
MBS1370687-002mgEColi 0.02mg(E-Coli)
EUR 595

Recombinant Morelia spilota Brain-derived neurotrophic factor (BDNF)
MBS1370687-002mgYeast 0.02mg(Yeast)
EUR 775

Recombinant Morelia spilota Brain-derived neurotrophic factor (BDNF)
MBS1370687-01mgEColi 0.1mg(E-Coli)
EUR 690

Recombinant Morelia spilota Brain-derived neurotrophic factor (BDNF)
MBS1370687-01mgYeast 0.1mg(Yeast)
EUR 910

SPI-112
T4340-10mg 10mg Ask for price
Description: SPI-112

SPI-112
T4340-1g 1g Ask for price
Description: SPI-112

SPI-112
T4340-1mg 1mg Ask for price
Description: SPI-112

SPI-112
T4340-50mg 50mg Ask for price
Description: SPI-112

SPI-112
T4340-5mg 5mg Ask for price
Description: SPI-112

SPI-112
HY-101964 10 mg
EUR 214.29
Description: SPI-112 is a potent, selective and competitive SHP2 (PTPN11) inhibitor with IC50s of 1 μM, 18.3 μM and 14.5 μM for SHP2, protein tyrosine phosphatase (PTP) and PTP1B, respectively[1][2].

SPI--112Me
T4627-10mg 10mg Ask for price
Description: SPI--112Me

SPI--112Me
T4627-1g 1g Ask for price
Description: SPI--112Me

SPI--112Me
T4627-1mg 1mg Ask for price
Description: SPI--112Me

SPI--112Me
T4627-50mg 50mg Ask for price
Description: SPI--112Me

SPI--112Me
T4627-5mg 5mg Ask for price
Description: SPI--112Me

SPI112Me
MBS3609348-5mg 5mg
EUR 240

SPI112Me
MBS3609348-5x5mg 5x5mg
EUR 750

SPI--112Me
MBS5750704-100mg 100mg
EUR 540

SPI--112Me
MBS5750704-50mg 50mg
EUR 385

SPI--112Me
MBS5750704-5mg 5mg
EUR 175

SPI--112Me
MBS5750704-5x100mg 5x100mg
EUR 2290

SPI1 (Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene spi1, OF, PU.1, SFPI1, SPI-1, SPI-A) (PE)
MBS6183786-01mL 0.1(mL
EUR 875

SPI1 (Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene spi1, OF, PU.1, SFPI1, SPI-1, SPI-A) (PE)
MBS6183786-5x01mL 5x0.1mL
EUR 3800

SPI1 (Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene spi1, OF, PU.1, SFPI1, SPI-1, SPI-A) (AP)
MBS6161736-01mL 0.1(mL
EUR 875

SPI1 (Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene spi1, OF, PU.1, SFPI1, SPI-1, SPI-A) (AP)
MBS6161736-5x01mL 5x0.1mL
EUR 3800

SPI1 (Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene spi1, OF, PU.1, SFPI1, SPI-1, SPI-A) (FITC)
MBS6174966-01mL 0.1(mL
EUR 875

SPI1 (Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene spi1, OF, PU.1, SFPI1, SPI-1, SPI-A) (FITC)
MBS6174966-5x01mL 5x0.1mL
EUR 3800

SPI1 (Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene spi1, OF, PU.1, SFPI1, SPI-1, SPI-A) (APC)
MBS6166146-01mL 0.1(mL
EUR 875

SPI1 (Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene spi1, OF, PU.1, SFPI1, SPI-1, SPI-A) (APC)
MBS6166146-5x01mL 5x0.1mL
EUR 3800

SPI1 (Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene spi1, OF, PU.1, SFPI1, SPI-1, SPI-A) (HRP)
MBS6179376-01mL 0.1(mL
EUR 875

SPI1 (Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene spi1, OF, PU.1, SFPI1, SPI-1, SPI-A) (HRP)
MBS6179376-5x01mL 5x0.1mL
EUR 3800

SPI1 (Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene spi1, OF, PU.1, SFPI1, SPI-1, SPI-A) (Biotin)
MBS6170556-01mL 0.1(mL
EUR 875

SPI1 (Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene spi1, OF, PU.1, SFPI1, SPI-1, SPI-A) (Biotin)
MBS6170556-5x01mL 5x0.1mL
EUR 3800

SPI1, 1-271aa, Human, His tag, E Coli (Denatured)
MBS205910-001mg 0.01mg
EUR 215

SPI1, 1-271aa, Human, His tag, E Coli (Denatured)
MBS205910-005mg 0.05mg
EUR 340

SPI1, 1-271aa, Human, His tag, E Coli (Denatured)
MBS205910-025mg 0.25mg
EUR 765

SPI1, 1-271aa, Human, His tag, E Coli (Denatured)
MBS205910-5x025mg 5x0.25mg
EUR 3195

SPI1 (Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene spi1, OF, PU.1, SFPI1, SPI-1, SPI-A) (MaxLight 405)
MBS6198038-01mL 0.1(mL
EUR 875

SPI1 (Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene spi1, OF, PU.1, SFPI1, SPI-1, SPI-A) (MaxLight 405)
MBS6198038-5x01mL 5x0.1mL
EUR 3800

SPI1 (Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene spi1, OF, PU.1, SFPI1, SPI-1, SPI-A) (MaxLight 490)
MBS6208713-01mL 0.1(mL
EUR 875

SPI1 (Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene spi1, OF, PU.1, SFPI1, SPI-1, SPI-A) (MaxLight 490)
MBS6208713-5x01mL 5x0.1mL
EUR 3800

SPI1 (Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene spi1, OF, PU.1, SFPI1, SPI-1, SPI-A) (MaxLight 550)
MBS6219388-01mL 0.1(mL
EUR 875

SPI1 (Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene spi1, OF, PU.1, SFPI1, SPI-1, SPI-A) (MaxLight 550)
MBS6219388-5x01mL 5x0.1mL
EUR 3800

SPI1 (Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene spi1, OF, PU.1, SFPI1, SPI-1, SPI-A) (MaxLight 750)
MBS6240738-01mL 0.1(mL
EUR 875

SPI1 (Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene spi1, OF, PU.1, SFPI1, SPI-1, SPI-A) (MaxLight 750)
MBS6240738-5x01mL 5x0.1mL
EUR 3800

SPI1 (Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene spi1, OF, PU.1, SFPI1, SPI-1, SPI-A) (MaxLight 650)
MBS6230063-01mL 0.1(mL
EUR 875

SPI1 (Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene spi1, OF, PU.1, SFPI1, SPI-1, SPI-A) (MaxLight 650)
MBS6230063-5x01mL 5x0.1mL
EUR 3800

SPI1 (NM_001080547) Human Over-expression Lysate
LS006688 100ug
EUR 628
Description: Transient overexpression lysate of spleen focus forming virus (SFFV) proviral integration oncogene spi1 (SPI1), transcript variant 1

Spib (untagged ORF) - Rat Spi-B transcription factor (Spi-1/PU.1 related) (Spib), (10 ug)
RN202347 10 µg Ask for price

Spic (untagged ORF) - Rat Spi-C transcription factor (Spi-1/PU.1 related) (Spic), (10 ug)
RN204207 10 µg Ask for price

SPIB (untagged)-Human Spi-B transcription factor (Spi-1/PU.1 related) (SPIB)
SC320776 10 µg Ask for price

SPIC (untagged)-Human Spi-C transcription factor (Spi-1/PU.1 related) (SPIC)
SC123240 10 µg Ask for price

SPIB (untagged)-Human Spi-B transcription factor (Spi-1/PU.1 related) (SPIB)
SC118169 10 µg Ask for price

SPIB (untagged)-Human Spi-B transcription factor (Spi-1/PU.1 related) (SPIB)
SC317377 10 µg Ask for price

Spic (GFP-tagged) - Mouse Spi-C transcription factor (Spi-1/PU.1 related) (Spic)
MG203000 10 µg Ask for price

SPIB (GFP-tagged) - Human Spi-B transcription factor (Spi-1/PU.1 related) (SPIB)
RG203170 10 µg Ask for price

SPIC (GFP-tagged) - Human Spi-C transcription factor (Spi-1/PU.1 related) (SPIC)
RG207166 10 µg Ask for price

SPI1 (27-37) goat polyclonal antibody, Aff - Purified
AP22967PU-N 50 µg Ask for price

Spic (untagged) - Mouse Spi-C transcription factor (Spi-1/PU.1 related) (Spic), (10ug)
MC209446 10 µg Ask for price

Spib (untagged) - Mouse Spi-B transcription factor (Spi-1/PU.1 related) (Spib), (10ug)
MC214320 10 µg Ask for price

Spib (Myc-DDK-tagged) - Mouse Spi-B transcription factor (Spi-1/PU.1 related) (Spib)
MR225440 10 µg Ask for price

Spib (GFP-tagged) - Mouse Spi-B transcription factor (Spi-1/PU.1 related) (Spib), (10ug)
MG225440 10 µg Ask for price

Spic (Myc-DDK-tagged) - Mouse Spi-C transcription factor (Spi-1/PU.1 related) (Spic)
MR203000 10 µg Ask for price

SPIC (Myc-DDK-tagged)-Human Spi-C transcription factor (Spi-1/PU.1 related) (SPIC)
RC207166 10 µg Ask for price

SPIB (Myc-DDK-tagged)-Human Spi-B transcription factor (Spi-1/PU.1 related) (SPIB)
RC203170 10 µg Ask for price

Spib (Myc-DDK-tagged ORF) - Rat Spi-B transcription factor (Spi-1/PU.1 related) (Spib), (10 ug)
RR202347 10 µg Ask for price

Spic (Myc-DDK-tagged ORF) - Rat Spi-C transcription factor (Spi-1/PU.1 related) (Spic), (10 ug)
RR204207 10 µg Ask for price

SPI1 (1-122) rabbit polyclonal antibody, Aff - Purified
AP23158PU-N 50 µl Ask for price

SPIRE1 (Protein Spire Homolog 1, SPIR1, Spir-1, KIAA1135) (AP)
MBS6133955-01mL 0.1(mL
EUR 875

SPIRE1 (Protein Spire Homolog 1, SPIR1, Spir-1, KIAA1135) (AP)
MBS6133955-5x01mL 5x0.1mL
EUR 3800

SPIRE1 (Protein Spire Homolog 1, SPIR1, Spir-1, KIAA1135)
MBS6006631-01mg 0.1(mg
EUR 630

SPIRE1 (Protein Spire Homolog 1, SPIR1, Spir-1, KIAA1135)
MBS6006631-5x01mg 5x0.1mg
EUR 2680

SPIRE1 (Protein Spire Homolog 1, SPIR1, Spir-1, KIAA1135) (PE)
MBS6160470-01mL 0.1(mL
EUR 875

SPIRE1 (Protein Spire Homolog 1, SPIR1, Spir-1, KIAA1135) (PE)
MBS6160470-5x01mL 5x0.1mL
EUR 3800

Lenti ORF clone of Spib (mGFP-tagged ORF) - Rat Spi-B transcription factor (Spi-1/PU.1 related) (Spib), (10 ug)
RR202347L4 10 µg Ask for price

Lenti ORF clone of Spic (mGFP-tagged ORF) - Rat Spi-C transcription factor (Spi-1/PU.1 related) (Spic), (10 ug)
RR204207L4 10 µg Ask for price

SPIRE1 (Protein Spire Homolog 1, SPIR1, Spir-1, KIAA1135) APC
MBS6139258-01mL 0.1(mL
EUR 875

SPIRE1 (Protein Spire Homolog 1, SPIR1, Spir-1, KIAA1135) APC
MBS6139258-5x01mL 5x0.1mL
EUR 3800

SPIRE2, ID (SPIRE2, KIAA1832, SPIR2, Protein spire homolog 2)
MBS6007257-02mL 0.2(mL
EUR 695

SPIRE2, ID (SPIRE2, KIAA1832, SPIR2, Protein spire homolog 2)
MBS6007257-5x02mL 5x0.2mL
EUR 2975

SPIRE1, CT (SPIRE1, KIAA1135, SPIR1, Protein spire homolog 1)
MBS643699-02mL 0.2mL
EUR 695

SPIRE1, CT (SPIRE1, KIAA1135, SPIR1, Protein spire homolog 1)
MBS643699-5x02mL 5x0.2mL
EUR 2975

SPIRE1, CT (SPIRE1, KIAA1135, SPIR1, Protein spire homolog 1) (AP)
MBS6350607-02mL 0.2mL
EUR 980

SPIRE1, CT (SPIRE1, KIAA1135, SPIR1, Protein spire homolog 1) (AP)
MBS6350607-5x02mL 5x0.2mL
EUR 4250

SPIRE1, CT (SPIRE1, KIAA1135, SPIR1, Protein spire homolog 1) (PE)
MBS6350617-02mL 0.2mL
EUR 980

SPIRE1, CT (SPIRE1, KIAA1135, SPIR1, Protein spire homolog 1) (PE)
MBS6350617-5x02mL 5x0.2mL
EUR 4250

SPIRE2, ID (SPIRE2, KIAA1832, SPIR2, Protein spire homolog 2) (AP)
MBS6350618-02mL 0.2mL
EUR 980

SPIRE2, ID (SPIRE2, KIAA1832, SPIR2, Protein spire homolog 2) (AP)
MBS6350618-5x02mL 5x0.2mL
EUR 4250

SPIRE2, ID (SPIRE2, KIAA1832, SPIR2, Protein spire homolog 2) (PE)
MBS6350628-02mL 0.2mL
EUR 980

SPIRE2, ID (SPIRE2, KIAA1832, SPIR2, Protein spire homolog 2) (PE)
MBS6350628-5x02mL 5x0.2mL
EUR 4250

SPIRE1 (Protein Spire Homolog 1, SPIR1, Spir-1, KIAA1135) (HRP)
MBS6155167-01mL 0.1(mL
EUR 875

SPIRE1 (Protein Spire Homolog 1, SPIR1, Spir-1, KIAA1135) (HRP)
MBS6155167-5x01mL 5x0.1mL
EUR 3800

SPI 112
MBS3607121-10mg 10mg
EUR 370

SPI 112
MBS3607121-25mg 25mg
EUR 660

SPI 112
MBS3607121-2mg 2mg
EUR 240

SPI 112
MBS3607121-50mg 50mg
EUR 995

SPI 112
MBS3607121-5mg 5mg
EUR 290

SPI 112
MBS5750110-10mg 10mg
EUR 145

SPI 112
MBS5750110-25mg 25mg
EUR 170

SPI 112
MBS5750110-50mg 50mg
EUR 220

SPI 112
MBS5750110-5x50mg 5x50mg
EUR 830

SPIRE1, CT (SPIRE1, KIAA1135, SPIR1, Protein spire homolog 1) (APC)
MBS6350608-02mL 0.2mL
EUR 980

SPIRE1, CT (SPIRE1, KIAA1135, SPIR1, Protein spire homolog 1) (APC)
MBS6350608-5x02mL 5x0.2mL
EUR 4250

SPIRE2, ID (SPIRE2, KIAA1832, SPIR2, Protein spire homolog 2) (APC)
MBS6350619-02mL 0.2mL
EUR 980

SPIRE2, ID (SPIRE2, KIAA1832, SPIR2, Protein spire homolog 2) (APC)
MBS6350619-5x02mL 5x0.2mL
EUR 4250

SPIRE1 (Protein Spire Homolog 1, SPIR1, Spir-1, KIAA1135) (FITC)
MBS6149864-01mL 0.1(mL
EUR 875