Staufen 1 amplifies proapoptotic activation of the unfolded protein response.

Staufen-1 (STAU1) is a protein RNA-binding becomes very overabundant in various models of neurodegenerative diseases, including those who carry mutations in presenilin1 (PSEN1), microtubule-associated protein tau (MAPT), huntingtin (HTT), TAR DNA-binding protein -43 gene (TARDBP), or C9orf72.

We previously reported that the increase in STAU1 determine defects and knockdown autophagy is protective in models of several neurodegenerative diseases. Additional functional consequences STAU1 overwhelming, however, has not been investigated. We studied the role of chronic activation STAU1 in the folded protein response (UPR), a common feature of neurodegenerative diseases and are often directly related to the death of neurons.

Here we report that STAU1 is a novel modulator of the UPR, and is required for apoptosis induced by activation of a perk-CHOP. STAU1 levels increase in response to some of the endoplasmic reticulum (ER) stress, and expression of exogenous STAU1 enough to cause apoptosis through pathways of UPR perk-CHOP. cortical neurons and skin fibroblasts derived from Stau1 – / – mice showed a decrease in the UPR and apoptosis when challenged with thapsigargin.

In fibroblasts from individuals with SCA2 or with ALS causes and C9ORF72 TDP-43 mutations, we found extremely elevated levels of STAU1 and CHOP in basal conditions, and STAU1 knockdown CHOP levels returned to normal. Taken together, these results suggest that STAU1 overabundance reduce cellular resistance to ER stress and apoptosis deposition.

Spill Tray Liner Small - PK10

SAF7080 PK10
EUR 66.15

Spill Tray Liner Large - PK10

SAF7082 PK10
EUR 121.5

Spill Tray ABS Yellow Large

SAF7086 EACH
EUR 91.2

Spill Tray PVC White Small - EACH

SAF7070 EACH
EUR 59.4

Spill Tray PVC White Large - EACH

SAF7074 EACH
EUR 110.7

Spill Tray ABS Yellow Small - EACH

SAF7084 EACH
EUR 71.55

Spill tray, polypropylene 14" x 10" x 1"

108DST10 each
EUR 88

Spill tray, polypropylene 14" x 20" x 1"

108DST20 each
EUR 106

Spill tray, polypropylene 24" x 24" x 1"

108DST24 each
EUR 133

SILICONE SPILLPROOF TOP - 2L FOR AL HSD STMTL

100DSI02 each
EUR 166

SILICONE SPILLPROOF TOP - 5L FOR AL HSD STMTL

100DSI05 each
EUR 206

SILICONE SPILLPROOF TOP - 12L FOR AL HSD STMTL

100DSI12 each
EUR 250

SILICONE SPILLPROOF TOP - 22L FOR AL HSD STMTL

100DSI22 each
EUR 339

Sensor, acrylic block for Spill Alarm & Cut Off

108ASP-AB each
EUR 188

HiCombat Microbiology Spillage Kit

LA734-1KT 1 unit
EUR 65.38
Description: HiCombat Microbiology Spillage Kit

Aluminum Glove Box 34" x 20" w/ spill tray & hygrometer

108CGB24-20 each
EUR 1797

Aluminum Glove Box 27" x 20" w/ spill tray & hygrometer

108CGB27-20 each
EUR 2146

Aluminum Glove Box 34" x 20" w/ spill tray & hygrometer

108CGB34-20 each
EUR 2211

IKA A11.7 funnel to prevent spilling of liquid Nitrogen - EACH

MIL2146 EACH
EUR 402.3

Spill Alarm & Cut-Off - with sensor block on 6' cable. One outlet, 1500W, 120V

108ASP-1 each
EUR 814

Absorbent Chemical Spill Response Kit 15L Clip-Top Bag - EACH

SAF3722 EACH
EUR 60.81

Absorbent Chemical Spill Response Kit 20L Clip-Top Bag - EACH

SAF3724 EACH
EUR 64.04

Absorbent Chemical Spill Response Kit 80L Circular Static Bin - EACH

SAF3716 EACH
EUR 177.72

SPI-112

T4340-10mg 10mg Ask for price
Description: SPI-112

SPI-112

T4340-1g 1g Ask for price
Description: SPI-112

SPI-112

T4340-1mg 1mg Ask for price
Description: SPI-112

SPI-112

T4340-50mg 50mg Ask for price
Description: SPI-112

SPI-112

T4340-5mg 5mg Ask for price
Description: SPI-112

SPI--112Me

T4627-10mg 10mg Ask for price
Description: SPI--112Me

SPI--112Me

T4627-1g 1g Ask for price
Description: SPI--112Me

SPI--112Me

T4627-1mg 1mg Ask for price
Description: SPI--112Me

SPI--112Me

T4627-50mg 50mg Ask for price
Description: SPI--112Me

SPI--112Me

T4627-5mg 5mg Ask for price
Description: SPI--112Me

Spi1/ Rat Spi1 ELISA Kit

ELI-20051r 96 Tests
EUR 1063.2

Spib (untagged ORF) - Rat Spi-B transcription factor (Spi-1/PU.1 related) (Spib), (10 ug)

RN202347 10 µg Ask for price

Spic (untagged ORF) - Rat Spi-C transcription factor (Spi-1/PU.1 related) (Spic), (10 ug)

RN204207 10 µg Ask for price

SPIC (untagged)-Human Spi-C transcription factor (Spi-1/PU.1 related) (SPIC)

SC123240 10 µg Ask for price

SPIB (untagged)-Human Spi-B transcription factor (Spi-1/PU.1 related) (SPIB)

SC118169 10 µg Ask for price

SPIB (untagged)-Human Spi-B transcription factor (Spi-1/PU.1 related) (SPIB)

SC317377 10 µg Ask for price

SPIB (untagged)-Human Spi-B transcription factor (Spi-1/PU.1 related) (SPIB)

SC320776 10 µg Ask for price

SPI1 (27-37) goat polyclonal antibody, Aff - Purified

AP22967PU-N 50 µg Ask for price

Spic (GFP-tagged) - Mouse Spi-C transcription factor (Spi-1/PU.1 related) (Spic)

MG203000 10 µg Ask for price

SPIC (GFP-tagged) - Human Spi-C transcription factor (Spi-1/PU.1 related) (SPIC)

RG207166 10 µg Ask for price

SPIB (GFP-tagged) - Human Spi-B transcription factor (Spi-1/PU.1 related) (SPIB)

RG203170 10 µg Ask for price

Spic (untagged) - Mouse Spi-C transcription factor (Spi-1/PU.1 related) (Spic), (10ug)

MC209446 10 µg Ask for price

Spib (untagged) - Mouse Spi-B transcription factor (Spi-1/PU.1 related) (Spib), (10ug)

MC214320 10 µg Ask for price

SPI1 (1-122) rabbit polyclonal antibody, Aff - Purified

AP23158PU-N 50 µl Ask for price

Spic (Myc-DDK-tagged) - Mouse Spi-C transcription factor (Spi-1/PU.1 related) (Spic)

MR203000 10 µg Ask for price

Spic (Myc-DDK-tagged ORF) - Rat Spi-C transcription factor (Spi-1/PU.1 related) (Spic), (10 ug)

RR204207 10 µg Ask for price

Spib (Myc-DDK-tagged ORF) - Rat Spi-B transcription factor (Spi-1/PU.1 related) (Spib), (10 ug)

RR202347 10 µg Ask for price

Spib (Myc-DDK-tagged) - Mouse Spi-B transcription factor (Spi-1/PU.1 related) (Spib)

MR225440 10 µg Ask for price

SPIC (Myc-DDK-tagged)-Human Spi-C transcription factor (Spi-1/PU.1 related) (SPIC)

RC207166 10 µg Ask for price

SPIB (Myc-DDK-tagged)-Human Spi-B transcription factor (Spi-1/PU.1 related) (SPIB)

RC203170 10 µg Ask for price

Spib (GFP-tagged) - Mouse Spi-B transcription factor (Spi-1/PU.1 related) (Spib), (10ug)

MG225440 10 µg Ask for price

PU.1/Spi1

E8ET7107-49 100ul
EUR 275
Description: Available in various conjugation types.

SPI1

pro-2174 2µg
EUR 60
Description: Recombinant Human Spi-1 Proto-Oncogene

SPI1

60B284 0.1mg
EUR 259

Lenti ORF clone of Spic (mGFP-tagged ORF) - Rat Spi-C transcription factor (Spi-1/PU.1 related) (Spic), (10 ug)

RR204207L4 10 µg Ask for price

Lenti ORF clone of Spib (mGFP-tagged ORF) - Rat Spi-B transcription factor (Spi-1/PU.1 related) (Spib), (10 ug)

RR202347L4 10 µg Ask for price

1000 ug/mL Spiromesifen in Acetone - 1ML

S-5296 1ML
EUR 206.55

Lenti ORF clone of Spic (mGFP-tagged) - Mouse Spi-C transcription factor (Spi-1/PU.1 related) (Spic)

MR203000L2 10 µg Ask for price

Lenti ORF clone of Spic (mGFP-tagged) - Mouse Spi-C transcription factor (Spi-1/PU.1 related) (Spic)

MR203000L4 10 µg Ask for price

Lenti ORF clone of Spic (Myc-DDK-tagged ORF) - Rat Spi-C transcription factor (Spi-1/PU.1 related) (Spic), (10 ug)

RR204207L3 10 µg Ask for price

Lenti ORF clone of Spib (Myc-DDK-tagged ORF) - Rat Spi-B transcription factor (Spi-1/PU.1 related) (Spib), (10 ug)

RR202347L3 10 µg Ask for price

Lenti ORF clone of Spib (mGFP-tagged) - Mouse Spi-B transcription factor (Spi-1/PU.1 related) (Spib)

MR225440L4 10 µg Ask for price

SPI1 Spi-1 Proto-Oncogene Human Recombinant Protein

PROTP17947 Regular: 10ug
EUR 380.4
Description: SPI1 Human Recombinant produced in E. coli is a single polypeptide chain containing 294 amino acids (1-271) and having a molecular mass of 33.6kDa.;SPI1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Lenti ORF clone of Spic (Myc-DDK-tagged) - Mouse Spi-C transcription factor (Spi-1/PU.1 related) (Spic)

MR203000L1 10 µg Ask for price

Lenti ORF clone of Spic (Myc-DDK-tagged) - Mouse Spi-C transcription factor (Spi-1/PU.1 related) (Spic)

MR203000L3 10 µg Ask for price

Lenti ORF clone of Spib (Myc-DDK-tagged) - Mouse Spi-B transcription factor (Spi-1/PU.1 related) (Spib)

MR225440L3 10 µg Ask for price

Spiroplasma citri Spiralin (spi)

1-CSB-EP322510FKO
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Spiroplasma citri Spiralin(spi) expressed in E.coli

1000 ug/mL Spirotetramat in HPLC Grade ACN - 1ML

S-5873 1ML
EUR 99.9

SPI1 (GFP-tagged) - Human spleen focus forming virus (SFFV) proviral integration oncogene spi1 (SPI1), transcript variant 2

RG212818 10 µg Ask for price

SPI1 (GFP-tagged) - Human spleen focus forming virus (SFFV) proviral integration oncogene spi1 (SPI1), transcript variant 1

RG217488 10 µg Ask for price

SPI1 (untagged)-Human spleen focus forming virus (SFFV) proviral integration oncogene spi1 (SPI1), transcript variant 2

SC127924 10 µg Ask for price

SPI1 (untagged)-Human spleen focus forming virus (SFFV) proviral integration oncogene spi1 (SPI1), transcript variant 2

SC317391 10 µg Ask for price

SPI1 (untagged)-Human spleen focus forming virus (SFFV) proviral integration oncogene spi1 (SPI1), transcript variant 1

SC315715 10 µg Ask for price

SPI1 siRNA

20-abx934949
  • Ask for price
  • Ask for price
  • 15 nmol
  • 30 nmol

SPI1 siRNA

20-abx934950
  • Ask for price
  • Ask for price
  • 15 nmol
  • 30 nmol

SPI1 siRNA

20-abx905245
  • Ask for price
  • Ask for price
  • 15 nmol
  • 30 nmol

Spin1 (untagged ORF) - Rat spindlin 1 (Spin1), (10 ug)

RN203467 10 µg Ask for price

Lenti ORF particles, Spic (GFP-tagged) - Mouse Spi-C transcription factor (Spi-1/PU.1 related) (Spic), 200ul, >10^7 TU/mL

MR203000L2V 200 µl Ask for price

Lenti ORF particles, Spic (GFP-tagged) - Mouse Spi-C transcription factor (Spi-1/PU.1 related) (Spic), 200ul, >10^7 TU/mL

MR203000L4V 200 µl Ask for price

Lenti ORF particles, Spic (GFP-tagged ORF) - Rat Spi-C transcription factor (Spi-1/PU.1 related) (Spic), 200ul, >10^7 TU/mL

RR204207L4V 200 µl Ask for price

Lenti ORF particles, Spib (GFP-tagged ORF) - Rat Spi-B transcription factor (Spi-1/PU.1 related) (Spib), 200ul, >10^7 TU/mL

RR202347L4V 200 µl Ask for price

Lenti ORF particles, Spib (GFP-tagged) - Mouse Spi-B transcription factor (Spi-1/PU.1 related) (Spib), 200ul, >10^7 TU/mL

MR225440L4V 200 µl Ask for price

1000 ug/mL Spinosad A and D in HPLC Acetonitrile - 1ML

LCS-6025 1ML
EUR 255.15

SPIN1 (untagged)-Human spindlin 1 (SPIN1)

SC108548 10 µg Ask for price

SPIN1 (untagged)-Human spindlin 1 (SPIN1)

SC322356 10 µg Ask for price

Coronavirus 2019 Spike (1000-1200 a.a.) Recombinant

rAP-5516 Inquiry Ask for price

Coronavirus 2019 Spike (800-1000 a.a.) Recombinant

rAP-5517 Inquiry Ask for price

Lenti ORF particles, Spic (Myc-DDK-tagged ORF) - Rat Spi-C transcription factor (Spi-1/PU.1 related) (Spic), 200ul, >10^7 TU/mL

RR204207L3V 200 µl Ask for price

Lenti ORF particles, Spib (Myc-DDK-tagged ORF) - Rat Spi-B transcription factor (Spi-1/PU.1 related) (Spib), 200ul, >10^7 TU/mL

RR202347L3V 200 µl Ask for price

Lenti ORF particles, SPIC (Myc-DDK tagged) - Human Spi-C transcription factor (Spi-1/PU.1 related) (SPIC), 200ul, >10^7 TU/mL

RC207166L1V 200 µl Ask for price

Lenti ORF particles, SPIC (mGFP-tagged) - Human Spi-C transcription factor (Spi-1/PU.1 related) (SPIC), 200ul, >10^7 TU/mL

RC207166L2V 200 µl Ask for price

Lenti ORF particles, SPIC (Myc-DDK tagged) - Human Spi-C transcription factor (Spi-1/PU.1 related) (SPIC), 200ul, >10^7 TU/mL

RC207166L3V 200 µl Ask for price

Lenti ORF particles, SPIC (mGFP-tagged) - Human Spi-C transcription factor (Spi-1/PU.1 related) (SPIC), 200ul, >10^7 TU/mL

RC207166L4V 200 µl Ask for price

Lenti ORF particles, SPIB (Myc-DDK tagged) - Human Spi-B transcription factor (Spi-1/PU.1 related) (SPIB), 200ul, >10^7 TU/mL

RC203170L1V 200 µl Ask for price

Lenti ORF particles, SPIB (mGFP-tagged) - Human Spi-B transcription factor (Spi-1/PU.1 related) (SPIB), 200ul, >10^7 TU/mL

RC203170L2V 200 µl Ask for price

Lenti ORF particles, SPIB (Myc-DDK tagged) - Human Spi-B transcription factor (Spi-1/PU.1 related) (SPIB), 200ul, >10^7 TU/mL

RC203170L3V 200 µl Ask for price

Lenti ORF particles, SPIB (mGFP-tagged) - Human Spi-B transcription factor (Spi-1/PU.1 related) (SPIB), 200ul, >10^7 TU/mL

RC203170L4V 200 µl Ask for price

SPI1 Mouse mAb

E2220729 100ul
EUR 225
Description: Available in various conjugation types.

SPI1 Mouse mAb

E2620355 100ul
EUR 225
Description: Available in various conjugation types.

anti-PU.1/Spi1

YF-PA14755 100 ug
EUR 483.6
Description: Rabbit polyclonal to PU.1/Spi1

SPI1 (Myc-DDK-tagged)-Human spleen focus forming virus (SFFV) proviral integration oncogene spi1 (SPI1), transcript variant 2

RC212818 10 µg Ask for price

SPI1 (Myc-DDK-tagged)-Human spleen focus forming virus (SFFV) proviral integration oncogene spi1 (SPI1), transcript variant 1

RC217488 10 µg Ask for price

1000 ug/mL Spinetoram in HPLC Acetonitrile - 1ML

LCS-6012 1ML
EUR 245.7

SPIN1 (GFP-tagged) - Human spindlin 1 (SPIN1)

RG201938 10 µg Ask for price

Lenti ORF particles, Spic (Myc-DDK-tagged) - Mouse Spi-C transcription factor (Spi-1/PU.1 related) (Spic), 200ul, >10^7 TU/mL

MR203000L1V 200 µl Ask for price

Lenti ORF particles, Spic (Myc-DDK-tagged) - Mouse Spi-C transcription factor (Spi-1/PU.1 related) (Spic), 200ul, >10^7 TU/mL

MR203000L3V 200 µl Ask for price

SPIB (GFP-tagged) - Homo sapiens Spi-B transcription factor (Spi-1/PU.1 related) (SPIB), transcript variant 3

RG231980 10 µg Ask for price

SPIB (GFP-tagged) - Homo sapiens Spi-B transcription factor (Spi-1/PU.1 related) (SPIB), transcript variant 2

RG233352 10 µg Ask for price

SPIB (GFP-tagged) - Homo sapiens Spi-B transcription factor (Spi-1/PU.1 related) (SPIB), transcript variant 4

RG233498 10 µg Ask for price

SPIB (untagged) - Homo sapiens Spi-B transcription factor (Spi-1/PU.1 related) (SPIB), transcript variant 3

SC330206 10 µg Ask for price

SPIB (untagged) - Homo sapiens Spi-B transcription factor (Spi-1/PU.1 related) (SPIB), transcript variant 2

SC332059 10 µg Ask for price

SPIB (untagged) - Homo sapiens Spi-B transcription factor (Spi-1/PU.1 related) (SPIB), transcript variant 4

SC332060 10 µg Ask for price

Lenti ORF particles, Spib (Myc-DDK-tagged) - Mouse Spi-B transcription factor (Spi-1/PU.1 related) (Spib), 200ul, >10^7 TU/mL

MR225440L3V 200 µl Ask for price

SPI1 Rabbit mAb

59789 100ul
EUR 339

SPI1 Rabbit mAb

E2R25501 100ul
EUR 255
Description: Available in various conjugation types.

SPI1 Rabbit mAb

E2R27214 100ul
EUR 255
Description: Available in various conjugation types.

SPI1 Rabbit pAb

E2382361 100ul
EUR 225
Description: Available in various conjugation types.

SPI1 Peptide

42-746P 0.1 mg
EUR 405.6
Description: (IN) PU.1 peptide

SPI1 Rabbit mAb

52847 100ul
EUR 499

SPI1 Rabbit mAb

52535 100ul
EUR 499

Anti-PU.1/Spi1 (2G1)

YF-MA10872 100 ug
EUR 435.6
Description: Mouse monoclonal to PU.1/Spi1

Anti-PU.1/Spi1 (1A3)

YF-MA15569 100 ug
EUR 435.6
Description: Mouse monoclonal to PU.1/Spi1

SPI1 Rabbit mAb

E2R382361 100ul
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

1000 ug/mL Spiroxamine in LCMS Acetonitrile - 1ML

LCS-5469 1ML
EUR 398.25

SPIB (Myc-DDK tagged) - Homo sapiens Spi-B transcription factor (Spi-1/PU.1 related) (SPIB), transcript variant 3

RC231980 10 µg Ask for price

SPIB (Myc-DDK tagged) - Homo sapiens Spi-B transcription factor (Spi-1/PU.1 related) (SPIB), transcript variant 2

RC233352 10 µg Ask for price

SPIB (Myc-DDK tagged) - Homo sapiens Spi-B transcription factor (Spi-1/PU.1 related) (SPIB), transcript variant 4

RC233498 10 µg Ask for price

1000 ug/mL Spiromesifen in HPLC Acetonitrile - 1ML

LCS-6035 1ML
EUR 230.85

Spin1 (Myc-DDK-tagged ORF) - Rat spindlin 1 (Spin1), (10 ug)

RR203467 10 µg Ask for price

SPI1 Antibody

33699 100ul
EUR 319

SPI1 Antibody

33699-100ul 100ul
EUR 302.4

SPI1 Antibody

33699-50ul 50ul
EUR 224.4

SPI1 Antibody

CSB-PA580989- each
EUR 402
Description: A polyclonal antibody against SPI1. Recognizes SPI1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

SPI1 Antibody

CSB-PA580989-100ul 100ul
EUR 379.2
Description: A polyclonal antibody against SPI1. Recognizes SPI1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

SPI1 Antibody

E033699 100μg/100μl
EUR 255
Description: Available in various conjugation types.

SPI1 Antibody

E11-10414C 100μg
EUR 225
Description: Available in various conjugation types.

SPI2B rabbit pAb

E28PT7211 100μl
EUR 255
Description: Available in various conjugation types.

PU.1/Spi1 Antibody

DF13270 100ul
EUR 420

PU.1/Spi1 Antibody

DF13270-100ul 100ul
EUR 280

PU.1/Spi1 Antibody

DF13270-200ul 200ul
EUR 350

SPI1 Antibody

1-CSB-PA003887
  • Ask for price
  • Ask for price
  • 100ug
  • 50ug
Description: A polyclonal antibody against SPI1. Recognizes SPI1 from Human, Mouse, Rat, Monkey. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/40000