Paulo Amaral

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My research focuses on the roles of noncoding RNAs (ncRNAs) in the regulation of chromatin structure and gene expression, especially in the context of animal development. We are developing chromatin isolation protocols to purify chromatin-associated RNAs ('caRNAs'), which are then identified by deep-sequencing. In my project, I also aim to identify specific long ncRNAs with regulated expression in mouse embryonic stem cells and developing embryo models, and to use knock-down and knock-in strategies to study their functions. The general goal is to elucidate mechanisms of action of individual transcripts and possibly identify functional classes of ncRNAs.

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